Tyrosine-protein kinase JAK1 antibody

Principal name

Tyrosine-protein kinase JAK1 antibody

Alternative names for Tyrosine-protein kinase JAK1 antibody

Janus kinase 1, JAK-1, JAK1A, JAK1B

SwissProt ID

O12990 (Danre), P23458 (Human), P52332 (Mouse)

Gene ID

3716 (JAK1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Tyrosine-protein kinase JAK1 antibody

JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation
of catalytic events. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

General readings

1. Sutherland JM  et al. Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation. J Cell Physiol 227:1188-98 (2012). IHC-P ; Mouse . PubMed: 21604262

Article(s) 1 à 20 sur un total de 21

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Anticorps Primaires

N° du Produit Hôte Isotype Clone Presentation Reactivité Applications  

Tyrosine-protein kinase JAK1 anticorps

  Rabbit anti-JAK1 (Phospho-Tyr1022) polyclonal antibody(Phospho-specific)  
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using JAK1 (phospho-Tyr1022) antibody. Rabbit IgG Purified Hu, Ms, Rt P
0.1 mg / 355,00 €
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 anticorps

  Rabbit anti-JAK1 polyclonal antibody  
Western blot analysis of extracts from MCF7 cells using JAK1 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / 450,00 €
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 anticorps

  Rabbit polyclonal JAK1 (Ab-1022) antibody  
Western blot analysis of extracts from A549, using JAK1 (Ab-1022) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / 335,00 €
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 anticorps

  Rabbit polyclonal anti-JAK1 antibody  
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JAK1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / 335,00 €
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 anticorps

  Rabbit polyclonal JAK1 (Tyr1022) antibody(Phospho-specific)  
Western blot analysis of extracts from A549 cells, using JAK1 (Phospho-Tyr1022) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms P, WB
0.1 ml / 335,00 €
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 anticorps

  Rabbit Polyclonal JAK1 Antibody  
Western blot analysis of JAK1 expression in EGF treated MCF7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / 335,00 €
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 pTyr1022 anticorps

Immunohistochemistry (IHC) analysis of JAK1 pTyr1022 antibody (Cat.-No.: AP01620PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms E, P
0.1 mg / 370,00 €
  OriGene Technologies GmbH

Tyrosine-protein kinase JAK1 pTyr1022 anticorps

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using JAK1 Antibody (Phospho-Tyr1022) Cat.-No AP02433PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / 300,00 €
  OriGene Technologies GmbH

Tyrosine-protein kinase JAK1 pTyr1022 anticorps

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using JAK1 Antibody (Phospho-Tyr1022) Cat.-No AP02433PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / 230,00 €
  OriGene Technologies GmbH

Tyrosine-protein kinase JAK1 anticorps

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JAK1 antibody AP02649PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / 300,00 €
  OriGene Technologies GmbH

Tyrosine-protein kinase JAK1 anticorps

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JAK1 antibody AP02649PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / 230,00 €
  OriGene Technologies GmbH

Tyrosine-protein kinase JAK1 pTyr1022 anticorps

Tyrosine-protein kinase JAK1 Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / 370,00 €
  OriGene Technologies GmbH

Tyrosine-protein kinase JAK1 anticorps

Tyrosine-protein kinase JAK1 Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / 370,00 €
  OriGene Technologies GmbH

CRISPR

N° du Produit Espèces Donor Vector  

JAK1 - human gene knockout kit via CRISPR

JAK1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / 1 290,00 €
  OriGene Technologies, Inc.

JAK1 - human gene knockout kit via CRISPR

JAK1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / 1 290,00 €
  OriGene Technologies, Inc.

JAK1 - human gene knockout kit via CRISPR

JAK1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / 1 290,00 €
  OriGene Technologies, Inc.

JAK1 - human gene knockout kit via CRISPR

JAK1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / 1 290,00 €
  OriGene Technologies, Inc.

Proteins & Growth Factors

N° du Produit Espèces Presentation Pureté Source  

Tyrosine-protein kinase JAK1

  Recombinant protein of human Janus kinase 1 (a protein tyrosine kinase) (JAK1)  
Tyrosine-protein kinase JAK1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / 788,00 €
  OriGene Technologies, Inc.

Lysates

N° du Produit    

JAK1 overexpression lysate

JAK1 overexpression lysate  
0.1 mg / 295,00 €
  OriGene Technologies, Inc.

Human Lenti ORF Particles

N° du Produit    

Lenti ORF particles, JAK1 (mGFP-tagged) - Human Janus kinase 1 (JAK1), 200 uL, >10^7 TU/mL

Lenti ORF particles, JAK1 (mGFP-tagged) - Human Janus kinase 1 (JAK1), 200 uL, >10^7 TU/mL  
200 µl / 1 400,00 €
  OriGene Technologies, Inc.

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