PTP4A2 antibody

Principal name

PTP4A2 antibody

Alternative names for PTP4A2 antibody

PRL2, PRL-2, PTPCAAX2, HU-PP-1, OV-1, Protein-tyrosine phosphatase 4a2, Protein tyrosine phosphatase type IVA 2, Protein-tyrosine phosphatase of regenerating liver 2

SwissProt ID

O70274 (Mouse), Q12974 (Human), Q6P9X4 (Rat)

Gene ID

8073 (PTP4A2), 19244 (Ptp4a2), 85237

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PTP4A2 antibody

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell sigling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-termil prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-termil prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II); and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype; which suggested its role in tumorigenesis. Altertively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11; 12 and 17.?

General readings

Si X., et al. (2001) J Biol chem. 246(35):32875-82.
Werner SR., et al. (2003) Cancer Lett. 202(2):201-11.

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