CD158F / KIR2DL5A antibody

Principal name

CD158F / KIR2DL5A antibody

Alternative names for CD158F / KIR2DL5A antibody

CD158F1, KIR2DL5, Killer cell immunoglobulin-like receptor 2DL5A

SwissProt ID

Q8N109 (Human)

Gene ID

57292 (KIR2DL5A)

Available reactivities

Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Flow Cytometry (F)

Background of CD158F / KIR2DL5A antibody

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by tural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory sigls upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kise binding protein to transduce activating sigls. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

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Anticorps Primaires

N° du Produit Hôte Isotype Clone Presentation Reactivité Applications  

CD158F / KIR2DL5A anticorps

CD158F / KIR2DL5A Mouse IgG1 UP-R1 PE Hu F
100 Tests / 290,00 €
  OriGene Technologies GmbH

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