ALDH3 antibody

Principal name

ALDH3 antibody

Alternative names for ALDH3 antibody

ALDH3A1, Aldehyde dehydrogenase 3, ALDHIII, Aldehyde dehydrogenase, dimeric NADP-preferring, Aldehyde dehydrogenase family 3 member A1

SwissProt ID

A3RF36 (Canfa), P11883 (Rat), P30838 (Human), P30907 (Bovin), P47739 (Mouse)

Gene ID

218 (ALDH3A1), 25375 (Aldh3a1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ALDH3 antibody

Aldh3A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldh3A1 is highly expressed in stomach and even more strongly in cornea, representing between 5 to 50% of the water soluble protein fraction in mammalian corneas. It is thought that Aldh3A1 acts to protect the cornea from UV-induced oxidative stress by not only detoxification of reactive aldehydes by also through the direct absorbtion of UV energy. However, corneas from Aldh3A1-null mice are indistinguishable from those from wild-type mice; mice lacking both Aldh3A1 and Aldh1A1 showed increased cataract formation following UVB exposure, suggesting that Aldh1A1 may be able to compensate for the loss of Aldh3A1. At least two isoforms of Aldh3A1 are known to exist. This antibody is predicted to have no cross-reactivity to Aldh3A2.

General readings

Estey T., et al. (2007) Exp Eye Res. 84(1):3-12
Bogucka M., et al. (2009) Acta Pol Pharm. 66(5):477-82.

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CRISPR

N° du Produit Espèces Donor Vector  

ALDH3A1 - human gene knockout kit via CRISPR

ALDH3A1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / 1 290,00 €
  OriGene Technologies, Inc.

1 article(s)

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