AR09983PU-N Sentan / SNTN (1-147, His-tag)

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0.1 mg / 300,00 €
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Sentan / SNTN

AR09983PU-N

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Description du Produit Sentan / SNTN

Sentan / SNTN.
Presentation: Purified

Caractéristiques du Produit Sentan / SNTN

Type de Produit Proteins & Growth Factors
Quantité 0.1 mg
Synonymes S100 calcium-binding protein A1-like, S100-A1-like, S100A1L
Presentation Purified
Poids Moléculaire 18.6 kDa
Source E. coli
Espèce (Protéine) Human
Destination Worldwide
Fiche Technique Télécharger la fiche technique
Fournisseur Acris Antibodies GmbH
Material Safety DataSheet (MSDS) MSDS for Proteins (de)

Extrait de la Fiche Technique

Immunogène
Swiss Prot:
A6NMZ2
Pureté > 90 %
Sujet SNTN, also known as Sentan, belongs to the S-100 family. SNTN is shown to localize exclusively to the bridging structure between the cell membrane and peripheral singlet microtubules, which specifically exists in the narrowed distal portion of cilia. Exogenously expressed sentan showed affinity for the membrane protrusions, and a protein-lipid binding assay revealed that sentan bound to phosphatidylserine. These findings suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport.
Concentration 0.5 mg/ml (determined by Bradford assay)
Références Générales Muzny D.M., et al. (2006) Nature. 440:1194-1198.
Kubo A., et al. (2008) Mol. Biol. Cell 19:5338-5346.
Stockage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human SNTN protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Séquence AA:
MGSSHHHHHH SSGLVPRGSH MGGCMHSTQD KSLHLEGDPN PSAAPTSTCA PRKMPKRISI SKQLASVKAL RKCSDLEKAI ATTALIFRNS SDSDGKLEKA IAKDLLQTQF RNFAEGQETK PKYREILSEL DEHTENKLDF EDFMILLLSI TVMSDLLQNI RNVKIMK
Poids Moléculaire:
(167aa), confirmed by MALDI-TOF
Presentation
Buffer:
20mM Tris-HCl buffer (pH 8.0) containing 50% glycerol, 0.15M NaCl, 1mM DTT
Pureté:
>90%
Format:
Liquid purified protein
Purified
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