PA1096XC Interleukin-19 (IL-19)

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Interleukin-19 (IL-19)

Description du Produit Interleukin-19 (IL-19)

Interleukin-19 (IL-19).
Presentation: Purified

Caractéristiques du Produit Interleukin-19 (IL-19)

Type de Produit Proteins & Growth Factors
Quantité 1 mg
Synonymes IL19
Presentation Purified
Poids Moléculaire 18 kDa
Source E. coli
Espèce (Protéine) Human
Destination Worldwide
Fiche Technique Télécharger la fiche technique
Fournisseur OriGene Technologies GmbH
Material Safety DataSheet (MSDS) MSDS for Proteins (de)

Extrait de la Fiche Technique

Pureté > 98 % Purified by proprietary chromatographic techniques, sterile Filtered, purity is greater than 99.0 % as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Sujet IL19 is a cytokine that belongs to the IL10 cytokine subfamily. IL-19 is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
Concentration 1 mg/ml (prior to lyophil.)
Références Générales
  1. Okayama N, Suehiro Y, Hamanaka Y, Nakamura J, Hinoda Y. Association of interleukin-19 gene polymorphisms with age. J Gerontol A Biol Sci Med Sci. 2007 May;62(5):507-11. PubMed PMID: 17522354.
  2. Zdanov A. Structural studies of the interleukin-19 subfamily of cytokines. Vitam Horm. 2006;74:61-76. PubMed PMID: 17027511.
  3. Hsing CH, Hsieh MY, Chen WY, Cheung So E, Cheng BC, Chang MS. Induction of interleukin-19 and interleukin-22 after cardiac surgery with cardiopulmonary bypass. Ann Thorac Surg. 2006 Jun;81(6):2196-201. PubMed PMID: 16731153.
  4. Chen PJ, Wei CC, Wang C, Chen FW, Hsu YH, Chang MS. Promoter analysis of interleukin 19. Biochem Biophys Res Commun. 2006 Jun 9;344(3):713-20. Epub 2006 Apr 7. PubMed PMID: 16631120.
  5. Otkjaer K, Kragballe K, Funding AT, Clausen JT, Noerby PL, Steiniche T, et al. The dynamics of gene expression of interleukin-19 and interleukin-20 and their receptors in psoriasis. Br J Dermatol. 2005 Nov;153(5):911-8. PubMed PMID: 16225599.
  6. Li HH, Lin YC, Chen PJ, Hsiao CH, Lee JY, Chen WC, et al. Interleukin-19 upregulates keratinocyte growth factor and is associated with psoriasis. Br J Dermatol. 2005 Sep;153(3):591-5. PubMed PMID: 16120148.
Stockage Lyophilized product is stable at room temperature for one month, should be stored desiccated below -20 °C. Upon reconstitution it should be stored at 2 – 8 °C up to one week and for future use below -20 °C. For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA). Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Source E.coli
Interleukin-19 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids.
Séquence AA:
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Arg-Arg-Cys.
Biological activity:
The activity is determined by it's ability to activate STAT following receptor-ligand interaction.
Poids Moléculaire:
17913 Dalton.
10 mM sodium citrate pH 5.
>98% Purified by proprietary chromatographic techniques, sterile Filtered, purity is greater than 99.0 % as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
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