AR10623PU-S HIV-2 gp36 env

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HIV-2 gp36 env


Description du Produit HIV-2 gp36 env

HIV-2 gp36 env.
Presentation: Purified

Caractéristiques du Produit HIV-2 gp36 env

Type de Produit Proteins & Growth Factors
Quantité 0.1 mg
Presentation Purified
Source E. coli
Destination Worldwide
Fiche Technique Télécharger la fiche technique
Fournisseur OriGene Technologies GmbH
Material Safety DataSheet (MSDS) MSDS for Proteins (de)

Extrait de la Fiche Technique

Pureté >95.0% pure as determined by 10.0% PAGE (coomassie staining).
Purification Method: DEAE sepharose, Affinity purification
Applications Antigen in ELISA and Western blots, excellent antigen for detection of HIV with minimal specificity problems.
Sujet HIV-1 and HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears and vaginal fluids. Immunodeficiency develops more slowly with HIV-2.
HIV-2 is less infectious in the early stages of the virus
han with HIV-1. The infectiousness of HIV-2 increases as the virus progresses. Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection and often some degree of CD4-independence. Despite considerable sequence and phenotypic differences between HIV-1 and 2 envelopes, structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal and C-terminal regions of the ectodomain, which is common to many viral and cellular fusion proteins and which seems to drive fusion.
HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature (25°C), does not require Ca2+ in the medium, is insensitive to treatment of target cells with cytochalasin B, and is not affected by target membrane glycosphingolipid composition. 
Concentration 1.0 mg/ml

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

The HIV-2 gp36 E.coli derived recombinant protein contains the HIV-2 immunodominant regions of env gp36.
Specificity: Immunoreactive with sera of HIV-2 infected individuals.
50mM TRIS-HCl, 8M Urea, pH 9.0
>95.0% pure as determined by 10.0% PAGE (coomassie staining).
Purification Method: DEAE sepharose, Affinity purification
Liquid sterile filtered colorless clear solution
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