NB110-81562

Caractéristiques du Produit 17-DMAG

Type de Produit Natural Compounds
Quantité 1 mg
Destination Not USA/Canada
Fiche Technique Télécharger la fiche technique
Fournisseur Novus Biologicals Inc.

Extrait de la Fiche Technique

Add. information Synthetic 17-DMAG
Soluble in DMSO (>25mg/mL) and ethanol (10mg/mL)
Purple solid
Applications , Synthetic 17-DMAG Soluble in DMSO (>25mg/mL) and ethanol (10mg/mL) Purple solid
Sujet 17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG.
Références Générales
  1. Bull E.E., et al.(2004) Clin. Cancer Res. 10:8077.
  2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96:381.
  3. Kaur G. et al.(2004) Clin. Cancer Res. 10:4813.
Stockage Store at -20C. Avoid freeze-thaw cycles.
Specificité
Specificité:
17-DMAG Compound
Espèces:
Not tested in other species.

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