NB110-81566

Caractéristiques du Produit Radicicol

Type de Produit Natural Compounds
Quantité 1 mg
Destination Not USA/Canada
Fiche Technique Télécharger la fiche technique
Fournisseur Novus Biologicals Inc.

Extrait de la Fiche Technique

Add. information Synthetic Radicicol, produced by fermentation. Soluble in DMSO. White to light yellow powder.
Applications , Synthetic Radicicol, produced by fermentation. Soluble in DMSO. White to light yellow powder.
Sujet Radicicol inhibits src (IC50=0.27μM) and src-like kinases, leading to hypophosphorylation of retinoblastoma tumor suppressor protein. It causes morphological reversion of ras-transformed cells and leads to selective depletion of Raf kinase. It also displays anti-angiogenic activity, and binds to and inhibits Hsp 90 molecular chaperone. It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1.f
Références Générales
  1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929.
  2. Yen A., et al. (1994) Exp.Cell Res. 214: 163.
  3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118:221.
  4. Soga S., et al. (1998) J.Biol.Chem. 273:822.
  5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241:221.
  6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260.
Stockage Store at -20C. Avoid freeze-thaw cycles.
Specificité
Specificité:
Radicicol Compound
Espèces:
Not tested in other species.

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