NB110-81559

Caractéristiques du Produit Geldanamycin

Type de Produit Natural Compounds
Quantité 1 mg
Synonymes Hsp90 inhibitor
Destination Not USA/Canada
Fiche Technique Télécharger la fiche technique
Fournisseur Novus Biologicals Inc.

Extrait de la Fiche Technique

Add. information Geldanamycin produced by fermentation.
>95% pure
Slightly soluble in methanol, chloroform or DMSO (10mg/mL); insoluble in water.
Yellow solid
Applications , Geldanamycin produced by fermentation. >95% pure Slightly soluble in methanol, chloroform or DMSO (10mg/mL); insoluble in water. Yellow solid
Sujet Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1
Références Générales 1. Whitesell L., et al. (1994) Proc. Natl. Acad. Sci. USA 91:8324.
2. Neckers L. (2002) Trends Mol. Med. 8: S55.
3. Mabjeesh N.J., et al. (2002) Cancer Res. 62: 2478.
4. Chavany C., et al. 1996) Amer. Society Biochem Mol Bio. 9: 4974-4977.
5. Villa R., et al. (2003) Carcinogenesis. 24(5): 851-9.
6. Yamaki H., Iguchi-Ariga S.M., and Ariga H. (1989) J
Antibiot (Tokyo) 42(4): 604-10.
Stockage Store at -20C. Avoid freeze-thaw cycles.
Specificité
Specificité:
Geldanamycin Compound
Espèces:
Not tested in other species.

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