TA328916 SLC8A2 / NCX2 anticorps

Rabbit polyclonal Anti-Na+/Ca2+ Exchanger 2 (NCX-2)

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0.2 ml / 622,00 €
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Rabbit anti Human, Mouse, Rat SLC8A2 / NCX2

TA328916

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  • TA328916

Description du Produit SLC8A2 / NCX2

Rabbit anti Human, Mouse, Rat SLC8A2 / NCX2.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Caractéristiques du Produit SLC8A2 / NCX2

Type de Produit Anticorps Primaires
Target Category
Quantité 0.2 ml
Synonymes KIAA1087, Na(+)/Ca(2+)-exchange protein 2, Sodium/calcium exchanger 2
Presentation Purified
Reactivité d'Espèce Hu, Ms, Rt
Applications WB
Clonalité Polyclonal
Hôte Rabbit
Destination Europe, USA/Canada
Fiche Technique Télécharger la fiche technique
Fournisseur OriGene Technologies, Inc.

Extrait de la Fiche Technique

Immunogène
Swiss Prot:
P48768
Immunogène:
Peptide (C)RVGDAQGMFEPDGG, corresponding to amino acid residues 486-499 of rat NCX-2. 3rd intracellular loop.
GeneID:
140447
Applications WB: 1:200-1:2000; IHC: 1:100-1:3000
Sujet Ca2+ has proven to be a universal sigling molecule in excitable and non-excitable cells. However, being that its intracellular concentration is 1000 time lower than the extracellular milieu, it is important for the cell to keep this ratio for proper function. NCX, a +/Ca2+ exchanger is responsible for most of the efflux of Ca2+ out from the cell1-3. The NCX transporter is a member of the SLC8 family of solute carriers which in turn belong to the CaCA superfamily.NCX-1 is one of three +/Ca2+ exchangers (NCX-1, NCX-2, NCX-3) leading to one Ca2+ movement across the plasma membrane in exchange of three + influx. However, the transporter can reverse the direction of the transport if the concentrations of + and Ca2+ change6. The transporter has nine transmembrane domains and intracellular N- and C-termils. Between tansmembrane domains 5 and 6, the presence of an extra-long intracellular loop, termed the f loop is responsible for regulating the activity of NCX-1 via several different mechanisms like ion binding, phosphorylation, etc. The f loop also has sites which undergo altertive splicing.Of the three NCX-1 expressed in mammalian cells, NCX-1 is the most widely expressed. Its expression is detected in the heart, brain, and kidney. NCX-1 undergoes altertive splicing in a tissue dependent manner. The first splice region does not change the overall structure of the protein but rather ebles the expression of the gene specific to the tissues which require the expression of the gene. The second splicing site leads to a number of proteins varying in length. NCX-2 expression is much more limited; it is expressed only in neurons. NCX-3 is expressed in skeletal muscle and in some regions of the brain and undergoes altertive splicing in a similar fashion to that of NCX-1.Due to their central role in modulating Ca2+ levels in the cell, NCX exchangers are involved in various pathophysiological diseases/disorders such as hypoxia, aging, alzheimerâ??s7, to me a few.
Presentation
Purification:
Affinity purified on immobilized antigen.
Buffer:
Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Format:
Purified

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