AM32149PU-N Rat Tumors, epithelial origin anticorps

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0.1 mg / 840,00 €
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Mouse anti Rat Rat Tumors, epithelial origin CC52

AM32149PU-N

Description du Produit Rat Tumors, epithelial origin

Mouse anti Rat Rat Tumors, epithelial origin CC52.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot, Immunoprecipitation, Paraffin Sections, Frozen Sections.

Caractéristiques du Produit Rat Tumors, epithelial origin

Type de Produit Anticorps Primaires
Quantité 0.1 mg
Synonymes Rat Tumor Marker
Presentation Purified
Reactivité d'Espèce Rt
Applications C, E, IP, P, WB
Clonalité Monoclonal
Clone CC52
Hôte Mouse
Isotype IgG1
Destination Worldwide
Fiche Technique Télécharger la fiche technique
Fournisseur Acris Antibodies GmbH
Material Safety DataSheet (MSDS) MSDS for Monoclonal Antibodies (de)

Extrait de la Fiche Technique

Immunogène
Immunogène:
Immunization of mice with Rat colon adenocarcinoma cells (CC531).
Remarques:
Hybridomas were selected for producing antibodies reacting with the CC531 cell line and with minimal cross reactivity to normal tissues (Hagenaars et al., 2001).
Isotype Control AM03095PU-N, SM20P (for use in rat samples)
Applications

ELISA. 
Western blotting. 
Flow Cytometry.
Immunoprecipitation.
Immunohistochemistry on Frozen Sections. 
Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Tissue:
There is some cross reactivity with intestinal epithelial tissue and bile ducts. Citric acid pretreatment is recommended.

Sujet

Common epithelial tumors begin in the surface epithelium of the ovaries and account for about 90% of all ovarian cancers. They are divided into a number of subtypes - including serous, endometrioid, mucinous, and clear cell tumors - that can be further classified as benign (noncancerous) or malignant (cancerous) tumors.

Références Générales
  1. Hagenaars M, Ensink NG, Basse PH, Hokland M, Nannmark U, Eggermont AM, et al. The microscopic anatomy of experimental rat CC531 colon tumour metastases: consequences for immunotherapy? Clin Exp Metastasis. 2000;18(2):189-96. PubMed PMID: 11235995.
  2. Hagenaars M, Koelemij R, Ensink NG, van Eendenburg JD, van Vlierberghe RL, Eggermont AM, et al. The development of novel mouse monoclonal antibodies against the CC531 rat colon adenocarcinoma. Clin Exp Metastasis. 2000;18(4):281-9. PubMed PMID: 11448057.
Stockage

Store undiluted at 2-8°C for Two months or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Presentation
Agent Conservateur:
0.05% Sodium Azide
Format:
Liquid purified Ig fraction
Purified
Reactivité d'Espèce
Reactivité d'Espèce (Testé):
Rat.
Specificité
Specificité:
CC52 is a Rat strain-independent marker for tumour cells of epithelial origin, such as colon, breast, or lung cancer, etc. When injected in colon tumour-bearing rats, CC52 localized to tumour cells (Hagenaars et al., 2001). 
CC52 has been used in many studies in a rat model of colorectal cancer (Hagenaars et al., 2000).
This Monoclonal antibody clone CC52 belongs to a first generation of such antibodies and is suitable to detect tumour cells by Immunohistochemistry. 
It binds to a dimer of two proteins, 120 kD and 130 kD, expressed by Rat tumour cells of epithelial origin. 
The antigens detected by CC52 are also expressed by IL-2-activated cultured NK cells and T cells and by bone marrow cells.

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