TA500641 PRKAR1A anticorps

anti-PRKAR1A (PKA regulatory subunit I alpha) mouse monoclonal antibody, clone OTI6C7 (formerly 6C7)

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0.1 ml / 379,00 €
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human PRKAR1A OTI6C7

TA500641

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Description du Produit PRKAR1A

Mouse anti Human PRKAR1A OTI6C7.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Caractéristiques du Produit PRKAR1A

Type de Produit Anticorps Primaires
Target Category
Quantité 0.1 ml
Synonymes CAR, CNC1, PKR1, PRKAR1, TSE1, Tissue-specific extinguisher 1, cAMP-dependent protein kinase type I-alpha regulatory subunit
Presentation Purified
Reactivité d'Espèce Hu
Applications ICC/IF, P, WB
Clonalité Monoclonal
Clone OTI6C7
Hôte Mouse
Isotype IgG1
Destination Europe, USA/Canada
Fiche Technique Télécharger la fiche technique
Fournisseur OriGene Technologies, Inc.

Extrait de la Fiche Technique

Immunogène
Swiss Prot:
P10644
Immunogène:
Full-length protein expressed in 293T cell transfected with human PRKAR1A expression vector.
GeneID:
5573
Isotype Control AM03095PU-N, SM10P (for use in human samples)
Applications WB 1:2000
IHC 1:50
IF 1:100
Sujet cAMP is a sigling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kise, which transduces the sigl through phosphorylation of different target proteins. The ictive kise holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the ictive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventiol nuclear localization sequence (NLS) has been found for this protein which suggests a role in D replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three altertively spliced transcript variants encoding the same protein have been observed.
Product Citations
Originator or purchased from resellers:
  1. Maleszewski JJ, Larsen BT, Kip NS, Castonguay MC, Edwards WD, Carney JA, et al. PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors. Am J Surg Pathol. 2014 Aug;38(8):1079-87. doi: 10.1097/PAS.0000000000000202. PubMed PMID: 24618615.
  2. Sousa SF, Gomez RS, Diniz MG, Bernardes VF, Soares FF, Brito JA, et al. Defects of the Carney complex gene (PRKAR1A) in odontogenic tumors. Endocr Relat Cancer. 2015 Jun;22(3):399-408. doi: 10.1530/ERC-15-0094. Epub 2015 Apr 13. PubMed PMID: 25870248. (Free PMC Article available)
Presentation
Purification:
Purified from mouse ascites fluids by affinity chromatography
Buffer:
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Format:
Purified

Accessory Products

Protéines et/ou Positive Controls

Protéines pour PRKAR1A (14 produits)

N° du Produit Espèces Presentation Pureté   Source  

PRKAR1A (transcript variant 1)

PRKAR1A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / 438,00 €
  OriGene Technologies, Inc.

PRKAR1A (transcript variant 2)

PRKAR1A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / 438,00 €
  OriGene Technologies, Inc.

PRKAR1A (transcript variant 3)

PRKAR1A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / 680,00 €
  OriGene Technologies, Inc.

PRKAR1A (active protein)

PRKAR1A Human Purified > 90.0% as determined by SDS-PAGE E. coli
  Acris Antibodies GmbH

PRKAR1A (active protein)

PRKAR1A Human Purified > 90.0% as determined by SDS-PAGE E. coli
  Acris Antibodies GmbH

PRKAR1A (active protein)

PRKAR1A Human Purified > 90.0% as determined by SDS-PAGE E. coli
  Acris Antibodies GmbH

PRKAR1A

PRKAR1A Human Purified > 95.0% as determined by SDS-PAGE. E. coli
  Acris Antibodies GmbH

PRKAR1A

PRKAR1A Human Purified > 95.0% as determined by SDS-PAGE. E. coli
  Acris Antibodies GmbH

PRKAR1A

PRKAR1A Human Purified > 95.0% as determined by SDS-PAGE. E. coli
  Acris Antibodies GmbH

PRKAR1A

PRKAR1A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

PRKAR1A

PRKAR1A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

PRKAR1A

PRKAR1A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

PRKAR1A

PRKAR1A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

PRKAR1A

PRKAR1A Human
  Abnova Taiwan Corp.

Positive Controls pour PRKAR1A (2 produits)

N° du Produit Espèces Presentation Pureté   Source  

PRKAR1A 293T Cell Transient Overexpression Lysate(Denatured)

PRKAR1A 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

Protein Kinase A regulatory subunit I alpha Lysate

Western Blot: Protein Kinase A regulatory subunit I alpha Lysate [NBL1-14765] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for PRKAR1A
  Novus Biologicals Inc.
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