NB100-649 LRP5 + LRP6 anticorps

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Mouse anti Human, Mouse LRP5 + LRP6 1A12


Description du Produit LRP5 + LRP6

Mouse anti Human, Mouse LRP5 + LRP6 1A12.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Caractéristiques du Produit LRP5 + LRP6

Type de Produit Anticorps Primaires
Quantité 50 µg
Synonymes LRP5, LRP6, LRP7, Low-density lipoprotein receptor-related protein 5, Low-density lipoprotein receptor-related protein 6
Presentation Purified
Reactivité d'Espèce Hu, Ms
Applications WB
Clonalité Monoclonal
Clone 1A12
Hôte Mouse
Isotype IgG2b
Destination Not USA/Canada
Fiche Technique Télécharger la fiche technique
Fournisseur Novus Biologicals Inc.

Extrait de la Fiche Technique

Synthetic peptide: DTGTDRIEVTR (Human). These residues are completely conserved between human and mouse; and between LRP 5 and LRP 6.
Isotype Control AM03110PU-N, SM12P
Add. information Research Areas: Neuroscience
Applications Western Blot, Western Blot , Western Blot 1-2 ug/ml
Sujet LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading to Axin degradation and beta catenin stabilization.
Concentration 1 mg/ml
Références Générales Li L et al. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem 277:5977-81 (2002). PUBMED:11742004
Stockage Store at -20C. Avoid freeze-thaw cycles.
IgG purified
Sodium Azide
IgG purified
This recognizes both full length and proteolytic fragments of LRP 6 and LRP 5.
Human, Mouse

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