AP09163PU-N Interleukin-13 / IL13 anticorps

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0.1 mg / 460,00 €
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Vue générale rapide

Rabbit anti Porcine Interleukin-13 / IL13

Description du Produit Interleukin-13 / IL13

Rabbit anti Porcine Interleukin-13 / IL13.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Caractéristiques du Produit Interleukin-13 / IL13

Type de Produit Anticorps Primaires
Target Category
Quantité 0.1 mg
Synonymes IL-13, NC30
Presentation Aff - Purified
Reactivité d'Espèce Por
Applications E, WB
Clonalité Polyclonal
Hôte Rabbit
Isotype IgG
Destination Worldwide
Fiche Technique Télécharger la fiche technique
Fournisseur OriGene Technologies GmbH
Material Safety DataSheet (MSDS) MSDS for Polyclonal Antibodies (de)

Extrait de la Fiche Technique

Immunogène
Swiss Prot:
Q95J68
Immunogène:
Full length recombinant protein raised in yeast, corresponding to mature swine IL-13 protein
GeneID:
396721
Applications ELISA: 1/11,000.
Western Blot: 1.5 - 2 µg/ml.
Sujet Interleukin 13 (IL-13), of the IL-4 superfamily, is a cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, that is an important mediator of allergic inflammation and disease. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Ra) and at least one IL-13-specific binding chain. Most of the biological effects of IL-13, like those of IL-4, are linked to a single transcription factor, STAT6. In humans, IL-13 can induce immunoglobulin E (IgE) secretion from activated B cells. In mice, deletion of IL-13 does not markedly affect either Th2 cell development or antigen-specific IgE responses induced by potent allergens. Deletion of IL-4 abrogates these responses. IL-13 acts as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thus altering physiological function. Although IL-13 is associated primarily with the induction of airway disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, it also induces airway matrix metalloproteinases as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation.
Concentration 1.0 mg/mL by UV absorbance at 280 nm
Références Générales
  1. Trigona WL, Brown WC, Estes DM. Functional implications for signaling via the IL4R/IL13R complex on bovine cells. Vet Immunol Immunopathol. 1999 Dec 15;72(1-2):73-9. PubMed PMID: 10614495.
  2. B.Lew, D.Lyles, K.Dempsey, Y.Zhao (2000) Mitogenic effect of IL-13 in bovine airway smooth muscle cells (ASMC). Journal of Allergy and Clinical Immunology, Volume 105, Issue 1, Page S299
Stockage Prior to reconstitution store at 2-8°C.
Following reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Presentation
Purification:
Affinity chromatography on Protein A
Buffer:
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
Format:
Lyophilized
Aff - Purified
Reconstitution:
Restore with 100 µL of deionized water or equivalent.
Reactivité d'Espèce
Species reactivity (expected):
Sheep, Dolphin, Beluga, Bovine, Human, Certain monkey, Dusky titi, Macaque, Baboon, Mangabey, Canine, Llama, Camel, Galago, Horse, Rat, Mouse, Gerbil.
Reactivité d'Espèce (Testé):
Porcine.
Specificité
Specificité:
This antibody reacts to Interleukin-13.
ID Gène 396721

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