NB100-94204 CAD anticorps

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Rabbit anti Mouse, Rat CAD

Description du Produit CAD

Rabbit anti Mouse, Rat CAD.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Caractéristiques du Produit CAD

Type de Produit Anticorps Primaires
Quantité 0.1 mg
Presentation Purified
Reactivité d'Espèce Ms, Rt
Applications WB
Clonalité Polyclonal
Hôte Rabbit
Isotype IgG
Destination Not USA/Canada
Fiche Technique Télécharger la fiche technique
Fournisseur Novus Biologicals Inc.

Extrait de la Fiche Technique

Rabbit anti-CAD (I17) polyclonal antibody was raised against a peptide corresponding to amino acids 205 to 222 of murine CAD (1).
Applications Western Blot, This polyclonal antibody can be used for detection of CAD by Western blot at 1:500 to 1:1000 dilution. Murine kidney tissue lysate can be used as positive control and a 40 kDa band should be detected. It is mouse and rat reactive., Western Blot 1:500-1:1000,
Sujet Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease) (1,2). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40 (3,4). Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively (5). Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei (1-4). Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.
Stockage Store at 4C. Do not freeze.
IgG purified
0.02% Sodium Azide
IgG purified
Mouse, Rat

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