AP55713PU-N BLM pThr99 anticorps

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0.1 mg / 340,00 €
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Vue générale rapide

Rabbit anti Human BLM

AP55713PU-N

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  • AP55713PU-N

Description du Produit BLM

Rabbit anti Human BLM.
Properties: pThr99
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Caractéristiques du Produit BLM

Type de Produit Anticorps Primaires
Target Category
Quantité 0.1 mg
Synonymes Bloom syndrome protein, DNA helicase, RECQ2, RECQL3, RecQ protein-like 3, RecQ-like type 2
Presentation Aff - Purified
Reactivité d'Espèce Hu
Applications P, WB
Clonalité Polyclonal
Hôte Rabbit
Poids Moléculaire 159 kDa
Destination Worldwide
Fiche Technique Télécharger la fiche technique
Fournisseur OriGene Technologies GmbH
Material Safety DataSheet (MSDS) MSDS for Polyclonal Antibodies (de)

Extrait de la Fiche Technique

Immunogène
Swiss Prot:
P54132
Immunogène:
Peptide sequence around phosphorylation site of threonine 99 (Q-E-T(p)-Q-R) derived from Human Bloom Syndrome (KLH-conjugated)
GeneID:
641
Caractéristiques pThr99
Applications Western blot: 1:500~1:1000.
Immunohistochemistry on paraffin sections: 1:50~1:100.
Sujet Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).
Concentration 1.0 mg/ml
Références Générales
  1. Ellis NA, Groden J, Ye TZ, Straughen J, Lennon DJ, Ciocci S, et al. The Bloom's syndrome gene product is homologous to RecQ helicases. Cell. 1995 Nov 17;83(4):655-66. PubMed PMID: 7585968.
  2. Karow JK, Chakraverty RK, Hickson ID. The Bloom's syndrome gene product is a 3'-5' DNA helicase. J Biol Chem. 1997 Dec 5;272(49):30611-4. PubMed PMID: 9388193.
  3. Pichierri P, Franchitto A, Rosselli F. BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks. EMBO J. 2004 Aug 4;23(15):3154-63. Epub 2004 Jul 15. PubMed PMID: 15257300. (Free PMC Article available, 7 images available)
Stockage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Presentation
Purification:
Affinity chromatography using epitope-specific peptide
Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Format:
Liquid Ig fraction
Aff - Purified
Reactivité d'Espèce
Reactivité d'Espèce (Testé):
Human
Specificité
Specificité:
The antibody detects endogenous levels of Bloom Syndrome Protein only when phosphorylated at threonine 99.

Accessory Products

Protéines et/ou Positive Controls

Protéines pour BLM (2 produits)

N° du Produit Espèces Presentation Pureté   Source  

BLM

BLM Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

BLM

BLM Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.
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