discontinued

AP55971PU-N Bax (N-term) anticorps

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Vue générale rapide

Rabbit anti Bovine, Canine, Chimpanzee, Feline, Human Bax

AP55971PU-N

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Description du Produit Bax

Rabbit anti Bovine, Canine, Chimpanzee, Feline, Human Bax.
Properties: (N-term)
Presentation: Purified
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Caractéristiques du Produit Bax

Type de Produit Anticorps Primaires
Quantité 0.2 mg
Synonymes BCL2-associated X protein, Bcl-2-like protein 4, apoptosis regulator BAX
Presentation Purified
Reactivité d'Espèce Bov, Can, Chimp, Fe, Hu
Applications C, ICC/IF, IP, WB
Clonalité Polyclonal
Hôte Rabbit
Destination Worldwide
Fiche Technique Télécharger la fiche technique
Fournisseur Acris Antibodies GmbH
Material Safety DataSheet (MSDS) MSDS for Polyclonal Antibodies (de)

Extrait de la Fiche Technique

Immunogène
Swiss Prot:
Q07815
Immunogène:
KLH-conjugated linear peptide corresponding to human BAX at and around the N-terminus.
Caractéristiques N-term
Applications Immunohistochemistry: 1:300 dilution from a previous lot detected BAX in colorectal and ductal carcinoma tissue.
Western Blot: 0.125 µg/ml of this antibody detected BAX on 10 µg of HL60 cell lysate.
Immunoprecipitation: 10 µg from a previous lot immunoprecipitated BAX from 500 µg of HL60 cell lysate.
Immunocytochemistry: 1:500 dilution from a previous lot detected BAX in MCF7 cells.
Sujet BAX (BCL2-associated X protein) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAX protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Concentration lot-specific
Stockage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Presentation
Purification:
Protein A Chromatography
Buffer:
0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Format:
Liquid purified Ig fraction
Purified
Specificité
Specificité:
This antibody recognizes BAX.
Demonstrated to react with human. Predicted to react with bovine, feline, rhesus monkey, chimpanzee, and canine based on 100% sequence homology. Rat (90%), Mouse (86%).

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