TA306644 AKIRIN1 (N-term) anticorps

Rabbit Polyclonal Akirin1 Antibody

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0.1 mg / 415,00 €
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Vue générale rapide

Rabbit anti Human, Mouse, Rat AKIRIN1

Description du Produit AKIRIN1

Rabbit anti Human, Mouse, Rat AKIRIN1.
Properties: (N-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Caractéristiques du Produit AKIRIN1

Type de Produit Anticorps Primaires
Target Category
Quantité 0.1 mg
Synonymes Akirin-1, C1orf108
Presentation Aff - Purified
Reactivité d'Espèce Hu, Ms, Rt
Applications E, WB
Clonalité Polyclonal
Hôte Rabbit
Isotype IgG
Destination Europe, USA/Canada
Fiche Technique Télécharger la fiche technique
Fournisseur OriGene Technologies, Inc.

Extrait de la Fiche Technique

Swiss Prot:
Akirin1 antibody was raised against a 16 amino acid peptide near the amino terminus of the human Akirin1. (AP30038CP-N)
Caractéristiques N-term
Add. information Blocking peptide available: blocking peptide (AP30038CP-N)
Applications ELISA.
Western Blot: Akirin1 antibody can be used for detection of Akirin1 at 1 – 2 μg/ml.
Sujet The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Références Générales
  1. Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, et al. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol. 2008 Jan;9(1):97-104. Epub 2007 Dec 9. PubMed PMID: 18066067. (Free PMC Article available, 8 images available)
  2. Beutler B and Moresco EM. Akirins versus infection. Nat. Immunol. 2008; 9:7-9.
  3. Sutterwala FS and Flavell RA. Immunology: cascade into clarity. Nature 2008; 451:254-5. 4. Tanji T and Ip YT. Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol. 2005; 26:193-8.
Stockage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Affinity chromatography purified via peptide column
PBS containing 0.02% sodium azide.
Liquid purified Ig fraction
Aff - Purified
This antibody reacts to AKIRIN1.
Human, Mouse, Rat.

Accessory Products

Protéines et/ou Positive Controls

Positive Controls pour AKIRIN1 (1 produits)

N° du Produit Espèces Presentation Pureté   Source  

AKIRIN1 overexpression lysate

AKIRIN1 overexpression lysate
0.1 mg / 295,00 €
  OriGene Technologies, Inc.
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