discontinued

AP16412PU-N Adenosine receptor A2b (C-term) anticorps

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Goat anti Human Adenosine receptor A2b

Description du Produit Adenosine receptor A2b

Goat anti Human Adenosine receptor A2b.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections.

Caractéristiques du Produit Adenosine receptor A2b

Type de Produit Anticorps Primaires
Target Category
Quantité 0.1 mg
Synonymes ADORA2B
Presentation Aff - Purified
Reactivité d'Espèce Hu
Applications E, P
Clonalité Polyclonal
Hôte Goat
Destination Worldwide
Fiche Technique Télécharger la fiche technique
Fournisseur OriGene Technologies GmbH
Material Safety DataSheet (MSDS) MSDS for Polyclonal Antibodies (de)

Extrait de la Fiche Technique

Immunogène
Swiss Prot:
P29275
Immunogène:
Peptide with sequence from the C Terminus of the protein sequence (NP_000667.1).
Séquence AA:
CQADVKSGNGQ
GeneID:
136
Caractéristiques C-term
Applications Peptide ELISA: 1/4000 (Detection Limit).
Western Blot: Preliminary experiments in Human Colon, Lung and Placenta lysates gave no specific signal but low background at antibody concentration up to 1 µg/ml.
Immunohistochemistry on Paraffin Sections: 2-4 µg/ml. In paraffin embedded Human Kidney shows cytoplasm staining in cells of renal tubules.
Sujet Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response, and the inhibition of protein synthesis. The adenosine receptors, including adenosine A1-R, adenosine A2A-R, adenosine A2B-R, and adenosine A3-R, are integral membrane proteins that are members of the G protein-coupled receptor family. The A1-R protein mediates ureagenesis in a partially calcium-dependent manner. Adenosine is known to mediate coronary vasodilation via the A2A-R receptor. Collagen synthasis and total protein synthesis are inhibited in certain cells by adenosine, acting via the A2B receptors. Activation of the A3-R receptor inhibits the induction of the cytokine TNFα and blocks the endotoxin CD14 receptor signal transduction pathway.
Concentration 0.5 mg/ml
Références Générales 1. Bazzichi L, Trincavelli L, Rossi A, De Feo F, Lucacchini A, Bombardieri S, Martini C. A2B adenosine receptor activity is reduced in neutrophils from patients with systemic sclerosis. Arthritis Res Ther. 2005;7(2):R189-95. Epub 2004 Dec 10.
PMID: 15743465
Stockage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Presentation
Purification:
Affinity Chromatography using the immunizing peptide.
Buffer:
Tris saline, pH~7.3
Agent Conservateur:
0.02% Sodium Azide
Stabilisateurs:
0.5% BSA
Format:
Liquid purified Ig fraction
Aff - Purified
Specificité
Specificité:
This anitbody recognizes Adenosine receptor A2b.
Espèces:
Human.
ID Gène 136
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