AP20251PU-N ACO1 / IREB1 anticorps

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0.1 mg / 350,00 €
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Vue générale rapide

Rabbit anti Human, Mouse, Rat ACO1 / IREB1

Description du Produit ACO1 / IREB1

Rabbit anti Human, Mouse, Rat ACO1 / IREB1.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections.

Caractéristiques du Produit ACO1 / IREB1

Type de Produit Anticorps Primaires
Target Category
Quantité 0.1 mg
Synonymes Aconitase, Citrate hydro-lyase, Cytoplasmic aconitate hydratase, Ferritin repressor protein, IRP1, Iron regulatory protein 1, Iron-responsive element-binding protein 1
Presentation Aff - Purified
Reactivité d'Espèce Hu, Ms, Rt
Applications ICC/IF, P
Clonalité Polyclonal
Hôte Rabbit
Poids Moléculaire ~ 98 kDa
Destination Worldwide
Fiche Technique Télécharger la fiche technique
Fournisseur OriGene Technologies GmbH
Material Safety DataSheet (MSDS) MSDS for Polyclonal Antibodies (de)

Extrait de la Fiche Technique

Immunogène
Swiss Prot:
P21399
GeneID:
48
Applications Immunoflourescence: 1/50-1/200.
Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Sujet The insulin receptor substrate-1 (IRS-1), a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor. The association of 14-3-3 with IRS-1 increases significantly upon treatment with okadaic acid, a potent serine/ threonine phosphatase inhibitor. Therefore, the association of 14-3-3 protein may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1.
Concentration 1.0 mg/ml
Stockage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Presentation
Purification:
Affinity Chromatography using epitope-specific immunogen.
Buffer:
Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
Format:
Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Aff - Purified
Reactivité d'Espèce
Species reactivity (expected):
Mouse and Rat.
Reactivité d'Espèce (Testé):
Human.
Specificité
Specificité:
This antibody detects endogenous levels of IRP-1 protein.
ID Gène 48

Accessory Products

Protéines et/ou Positive Controls

Protéines pour ACO1 / IREB1 (12 produits)

N° du Produit Espèces Presentation Pureté   Source  

ACO1 / IREB1

ACO1 / IREB1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / 680,00 €
  OriGene Technologies, Inc.

ACO1 / IREB1 (1-889, His-tag)

ACO1 / IREB1 Human Purified > 90 % E. coli
50 µg / 750,00 €
  OriGene Technologies GmbH

ACO1 / IREB1 (1-889, His-tag)

ACO1 / IREB1 Human Purified > 90 % E. coli
10 µg / 300,00 €
  OriGene Technologies GmbH

ACO1 / IREB1

ACO1 / IREB1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

ACO1 / IREB1

ACO1 / IREB1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

ACO1 / IREB1

ACO1 / IREB1 Human Purified
  Abnova Taiwan Corp.

ACO1 / IREB1

ACO1 / IREB1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

ACO1 / IREB1

ACO1 / IREB1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

ACO1 / IREB1

ACO1 / IREB1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

ACO1 / IREB1

ACO1 / IREB1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

ACO1 / IREB1

ACO1 / IREB1 Human Purified
  Novus Biologicals Inc.

ACO1 / IREB1

ACO1 / IREB1 Human Purified
  Novus Biologicals Inc.

Positive Controls pour ACO1 / IREB1 (2 produits)

N° du Produit Espèces Presentation Pureté   Source  

ACO1 293T Cell Transient Overexpression Lysate(Denatured)

ACO1 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

Aconitase 1 Lysate

Western Blot: Aconitase 1 Lysate [NBL1-07243] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for ACO1 Protein
  Novus Biologicals Inc.
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